参与免疫及炎症反应调控的胞浆蛋白NODs.pdfVIP

( ) ·1304 · 中国病理生理杂志 　Chinese Journal of Pathophysiology 　2004 ,20 7 :1304 - 1308 ( ) [文章编号] 　1000 - 4718 2004 07 - 1304 - 05 ·综 　述 · 参与免疫及炎症反应调控的胞浆蛋白 NODs 胡巢凤 (暨南大学医学院病理生理学教研室 , 广东 广州 510632) Cytosolic proteins NODs involved in the regulation of immune and infla mmatory responses HU Chao - feng ( Dep artment of Pathop hysiology , Medical College of J inan University , Guangz hou 510632 , China) 　　【A Revie w】　Nucleotide - binding oligomerization domain (NOD) proteins are members of a growing family of cytosolic factors related to the apoptosis regulator Apaf - 1 and a class of plant disease resistance pro κ teins. NOD proteins have been implicated in the induction of NF - B activity and in the activation of caspas es. Biochemical evidence has unraveled the role of NOD1 and NOD2 as intracellular sensors of bacterial pepti doglycan . Notably , genetic variation in the genes encoding the NOD proteins NOD2 , cryopyrin and C ⅡTA in humans is associated with inflammatory disease or increased susceptibility to bacterial infections. NOD proteins may be involved in the recognition of microorganisms and regulation of inflammatory responses. 　　[ 关键词] 　NOD 蛋白; 炎症 ; 免疫 ; 凋亡 　　[ KEY WORDS] 　NOD proteins ; Inflammation ; Immunity ; Apoptosis 　　[ 中图分类号] 　R363 　　　　　[文献标识码] 　A 　　机体接触致病微生物后迅速对病原体进行识别 细菌的识别及诱导炎症反应[2 ] 。 并产生抵抗病原体入侵的反应 ,发挥这一功能的主