中草药及复方抗乙肝病毒s、e抗原的研究与疗效.docVIP

???? 中草药及复方抗乙肝病毒s、e抗原的研究与疗效 ???? ????摘要：目的　中草药及复方抗乙肝病毒s、e抗原的实验研究及疗效观察。方法　应用反向被动血凝抑制(RPHI)法和酶联免疫吸附检测(ELISA)法筛选出抗HBsAg高效中草药组成复方。结果　服用2个疗程e抗原阴转率51%，与干扰素疗效相似，服用4个疗程则可明显提高疗效。结论　中草药复方辩证治疗慢性乙肝，对HBsAg、HBeAg、HBV-DNA转阴，抗HBs、抗HBe转阳取得了较好的疗效，长期服用可防止复发。关键词：慢性乙型肝炎；中草药及复方；疗效中分类号：R512.6+2　　　文献标识码：A　　　文章编号：1001-8174(2000)04-0197-02 Experimental and Clinical Study of Composite Prescriptions of Chinese Herbal Medicine against HBsAg and HBeAg CHEN Hong-yi，LI Yu-bing，（The Ninth Hospital of Nanchang City,Nanchang 330002,China）GAN Chun，WAN Yi-peng，（The Affiliated Hospital of Jiangxi College of Traditional Chinese Medicine,Nanchang 330006,China）ZHENG Min-shi，LI Wen（Department of Microbiology,Jiangxi Medical College,Nanchang 330006,China） Abstract：Objective　To observe the efficacy of composite prescriptions of Chinese herbal medicine against HBsAg and HBeAg.Method　Patients took the higher effective composite prescriptions of Chinese herbal medicine selected with the two means of RPHI and ELISA.Results　51% of their HBeAgs became negative in two courses of treatment.The curative effect was similar to that of interferon.The curative effect would be more obvious if four courses of treatment were given.Conclusions　The therapeutic effect of composite prescriptions of Chinese herbal medicine,in making HBsAg,HBeAg and HBV-DNA negative,and making anti-HBs and anti-HBe positive was very good because the dielectical treatment was adopted.Besides,the relapse of chronic hepatitis B can be prevented if every patient receives a long-term treatment.Key words：Chronic Hepatitis B;Composite prescriptions of Chinese herbal medicine;Therapeutic effect 　　干扰素是治疗慢性乙肝较有效药物，近期疗效50%左右，但复发率很高［1，2］。自1995年8月以来，我们用反向被动血凝抑制(RPHI)法［3］和酶联免疫吸附检测(ELISA)法［4］筛选出抗HBsAg高效中草药组成复方加减治疗慢性乙肝100例，对HBsAg、HBeAg、HBV-DNA转阴，抗HBs、抗HBe转阳取得了较好的疗效，报告如下。 1　材料与方法 1.1　临床资料　门诊乙肝患者100例，其中男83例，女17例，年龄15～60岁，病程0.5～2年，按1995年5月北京第5次全国传染病寄生虫病学术会议标准，均符合慢性病毒性肝炎(乙型)诊断。其血清HBV标志检测(ELISA)均为HBsAg、HBeAg、HBV-DNA(PCR)阳性，肝功能检查血清ALT为44～340U/L，平均168U/L，持续时间