大气可吸入颗粒物对肺组织损伤机制的研究进展.pdf

19 1 Vol. 19, No. 1 2007 2 Chinese Bulletin of Life Sciences Feb., 2007 1004-0374(2007)01-0078-05 1 , 100037 2 100083 (PM 10) X513 X503.1 A The study on the mechanism of lung injury by induction of inhaled particle matter 1 2 JIANG Wei , ZHAO Xiaohong * (1 School of Life Sciences, Capital Normal University, Beijing 100037, China; 2 College of Applied Arts and Sciences, Beijing Union University, Beijing100083, China) Abstract: Many epidemiologic studies have shown that the increase in mortality of cardiovascular and respira- tory diseases is closely associated with elevated level of ambient respirable particulate matter, however, the toxicological mechanisms of PM 10 still remain unresolved. The study progress in oxidative damage and inflam- matory injury effects of PM on alveolar tissue were reviewed. 10 Key word: respirable particulate matter; oxidative damage; inflammation damage; mechanism of injury 50 10µm (PM (PM 3 10) 2.5)10µg/m 4% 6% 8% 1985 1994 4 757 PM NO