急性肾炎培训演示课件.pptVIP

Pathology Normal glomerulus AGN Pathology Pathology With infiltration by hematogenous cells, most notably PMNS Pathology In AGN, immunofluorescent studies show finely granular staining for IgG in peripheral capillary loops and in mesangial areas Pathogenesis Nephritis strain（Ag） CIC/IC Depositing within glomeruli and stimulate the fixation of complement/antibody Diffuse proliferative GBM injury GFR↓ oliguria overload edema hypertention Hematuria proteinuria Frequency of clinical Manifestations in APSGN Gross hematuria 25 – 33 % Volume overload Edema