脑卒中神经修复治疗方向细胞治疗.pptVIP

Schematic illustrating the different cells and routes of administration used in published trials. The schematic also illustrates other types of cells used in registered trials (in dotted rectangles). NT2N, human teratocarcinoma-derived neurons; UC-MSCs, umbilical cord-derived mesenchymal stem cells; UCB-MNCs, umbilical cord blood-mononuclear cells; BM-MNCs, bone marrow-mononuclear cells; BM-MSCs, bone marrow-mesenchymal stem cells; PB-HSPC, peripheral blood-hematopoietic stem/progenitor cell; NSPCs, neural stem/progenitor cells; OECs, olfactory-ensheathing cells; MSCs, mesenchymal stem cells; EPCs, endothelial progenitor cells there are several obstacles to the use of NSPC from these two sources in clinical trials in stroke. For instance, the need for multiple fetal donors to treat a single patient could raise ethics concerns and may not be feasible in large-scale trials. Moreover, the isolation of adult NSPC for autologous transplantation would require brain biopsies and many days in culture for expansion, and may have some limitations, In this regard, it has been shown that an intravenous administration of bone marrow-derived MSC promotes a similar degree of functional recovery to bone marrow-derived mononuclear cell transplantation in a rodent model of stroke, as long as the dose is optimized for each cell type [59]. Another study showed that there was no difference in the therapeutic effects of bone marrow-derived and umbilical cord tissue-derived MSCs (UC-MSCs) in a model of focal ischemia Following vascular occlusion, a complex chain of events occurs at a molecular level, leading to irreversible tissue injury, including ..... It is a critical step for the transplanted cells to survive first before it take effect. The expression of pluripotent potent and neural markers during the induction process of the iPSCs to NSCs. Immunocytochemistry staining shows that the spheres expressed the neural precursor markers Nestin(A), Sox2(B) induced by RA and serum-free m