天然产物研究Neofipiperzine D, a new prenylated indole alkaloid metabolite of the fungus Neosartorya fischeri.pdfVIP

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天然产物研究Neofipiperzine D, a new prenylated indole alkaloid metabolite of the fungus Neosartorya fischeri.pdf

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JOURNAL OF CHEMICAL RESEARCH 2014 VOL. 38 SEPTEMBER, 539–541 RESEARCH PAPER 539 Neofipiperzine D, a new prenylated indole alkaloid metabolite of the fungus Neosartorya fischeri a a d a d c Bing‑Yu Chen , Zhen Wang , You‑Min Ying , Lu‑Xi Jiang , Zha‑Jun Zhan , Jun‑Lu Wang and Wei Zhanga,b* a Institute of Molecular Medicine, Department of Blood Transfusion, Zhejiang Provincial People’s Hospital, Hangzhou, 310014, P.R. China bDepartment of Gastrointestinal Surgery, Zhejiang Provincial People’s Hospital, Hangzhou, 310014, P.R. China cDepartment of Anesthesia, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, P.R. China dCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, P.R. China A new prenylated indole alkaloid, neofipiperzine D, was isolated from the cultures of Neosartorya fischeri, together with three known metabolites fumitremorgin C, ergosterol, and ergosterol peroxide. The structure of the new compound was established by detailed analysis of its spectroscopic data, especially 1D, 2D NMR and HR‑ESI‑MS data. In an in vitro assay, neofipiperzine D did not exhibit any significant cytotoxicity against MCF‑7, H1299, HUVEC, and MDA‑MB‑231 cell lines at a concentration of 20 µM. Keywords: Neosartorya fischeri, diketopiperazine, alkaloid, fumitremorgin C Prenylated indole alkaloids are hybrid natural products derived group as compared with 2. The structure of the prenyl unit from prenyl diphosphates and