原创力文档天然产物研究New chaetoglobosin derivatives, MBJ-0038, MBJ-0039 and MBJ-0040, isolated from the fungus Chaetomium sp. f24230.pdfVIP
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The Journal of Antibiotics (2013) 66, 727–730
2013 Japan Antibiotics Research Association All rights reserved 0021-8820/13
/ja
NOTE
New chaetoglobosin derivatives, MBJ-0038,
MBJ-0039 and MBJ-0040, isolated from the
fungus Chaetomium sp. f24230
1 2 1 2 2 3
Teppei Kawahara , Masashi Itoh , Miho Izumikawa , Noriaki Sakata , Toshio Tsuchida and Kazuo Shin-ya
The Journal of Antibiotics (2013) 66, 727–730; doi:10.1038/ja.2013.75; published online 24 July 2013
Keywords: chaetoglobosin; Chaetomium; cytotoxic
We screened a library constructed by the advanced compound- acetate (0–25% ethyl acetate) followed by CHCl3–methanol (MeOH)
identification system based on the accumulated HPLC-MS profiling with stepwise increases from 0 to 100% MeOH with monitoring by
data combined with strain information designated as ‘MBJ’s special UV at 254 nm. The active 5% MeOH fraction (190.1 mg) was
selection’ for bioactive substances, and have isolated five novel separated by gel filtration on a Sephadex LH-20 column (1:1,
eremophilane sesquiterpenoids MBJ-0009 and -0010 from the CHCl3/MeOH, GE Healthcare BioSciences AB, Uppsala, Sweden)
saprobic fungus Nectria sp. and MBJ-0011, -0012 and -0013 from followed by reversed phase-MPLC (Purif-Pack ODS-30; 70–100% aq.
the endophytic fungus Apiognomonia sp.1,2 Further screening for MeOH wi
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