天然产物研究New and highly potent antitumor natural products from marine-derived fungi covering the period from 2003 to 2012.pdfVIP

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天然产物研究New and highly potent antitumor natural products from marine-derived fungi covering the period from 2003 to 2012.pdf

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Send Orders for Reprints to reprints@ Current Topics in Medicinal Chemistry, 2013, 13, 2745-2766 2745 New and Highly Potent Antitumor Natural Products from Marine-Derived Fungi: Covering the Period from 2003 to 2012 1,* 2 3 1,* Boris Pejin , Katarina K. Jovanovi , Milo Mojovi and Aleksandar G. Savi 1 University of Belgrade, Institute of Multidisciplinary Research - IMSI, Kneza Viseslava 1, 11030 Belgrade, Serbia; 2Institute of Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia; 3 University of Belgrade, Faculty of Physical Chemistry, Studentski trg 12-16, 11158 Belgrade, Serbia Abstract: This review covers the 2003-2012 literature data published for antitumor natural products from marine-derived fungi. The focus is on new and highly potent cytotoxic compounds, together with details related to the relevant fungal species. It describes 22 promising bioactives, originating mainly from symbiotic fungi. The chemical structures of all highlighted organic molecules are briefly discussed. Keywords: Antitumor activity, marine-derived fungi, novel leads, secondary metabolites. INTRODUCTION NRPS (polyketide synthase – non-ribosomal peptide syn- thase) hybrids, e.g. responsible for the generation of pseu- The purpose of this review is to consolidate the research