天然产物研究New prenylated indole alkaloids from fungus Penicillium sp derived of mangrove soil sample.pdfVIP

Tetrahedron 70 (2014) 3859e3863 Contents lists available at ScienceDirect Tetrahedron journal homepage: www.el /locate/tet New prenylated indole alkaloids from fungus Penicillium sp. derived of mangrove soil sample Bin Yang, Junde Dong, Xiuping Lin, Xuefeng Zhou, Yanying Zhang, Yonghong Liu * CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, China a r t i c l e i n f o a b s t r a c t Article history: Three diprenylated indole alkaloids, mangrovamides AeC (1e3), featured a bicyclo [2.2.2] diazaoctane Received 29 January 2014 core and possessed a novel g-methyl proline and isoprene derived dimethyl g-pyrone functionalities Received in revised form 29 March 2014 hitherto unknown among the family of paraherquamides, were isolated from the fungus Penicillium sp., Accepted 15 April 2014 which was separated from a mangrove soil sample. The structures were elucidated based on NMR, X-ray, Available online 23 April 2014 and CD methods. The possible biosynthetic pathway of these compounds is proposed. 2014 Elsevier Ltd. All rights reserved. Keywords: Penicillium sp. Prenylated indole alkaloids Mangrovamides X-ray diffraction Anti-acetylcholinesterase activity 1.