天然产物研究Cristatumins A-D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220.pdfVIP

Bioorganic Medicinal Chemistry Letters 22 (2012) 4650–4653 Contents lists available at SciVerse ScienceDirect Bioorganic Medicinal Chemistry Letters journal homepage: /locate/bmcl Cristatumins A–D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220 Feng-Yu Du a,b, Xiao-Ming Li a, Chun-Shun Li a, Zhuo Shang a, Bin-Gui Wang a,⇑ a Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China b Graduate School of the Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China a r t i c l e i n f o a b s t r a c t Article history: Four new indole alkaloids, namely, cristatumins A–D (1–4), along with six known congeners (5–10) were Received 23 March 2012 identified from the culture extract of Eurotium cristatum EN-220, an endophytic fungus isolated from the Revised 18 May 2012 marine alga Sargassum thunbergii. The structures of these compounds were established on the basis of Accepted 24 May 2012 extensive spectroscopic analysis. Each of these compounds was evaluated for antimicrobial and insecti- Available online 1 June 2012 cidal activity. Compounds 1 and 9 showed antibacterial activity against Escherichia coli and Staphyloccocus aureus, respectively, while compounds 2, 6, and 7 exhibited moderate lethal activity against brine shrimp. Keywords: Preliminary structure–activity relationshi