IAP家族分子与肿瘤靶向治疗.PDFVIP

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IAP家族分子与肿瘤靶向治疗.PDF

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22 2 Vol. 22, No. 2 2010 2 Chinese Bulletin of Life Sciences Feb., 2010 1004-0374(2010)02-0161-08 IAP (/ 100021) (inhibitor of apoptosis proteins, IAPs) Caspase NF- κB IAPs IAP I A P Q255 R73-362 A IAP family and IAP-targeted cancer therapy XU Yang, ZHAO Xiao-hang* (State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing 100021, China) Abstract: The inhibitor of apoptosis proteins (IAPs) are known as a group of highly conserved endogenous proteins that regulate the activity of caspases and NF-kB survival pathways. The mechanism of resistant apoptosis has played a crucial role in the tumorigenesis, tumor progress and drug resistance. Overexpression of IAPs has been shown to confer protection against a number of apoptosis in a variety of stress and is believed to have important consequences with respect to human cancer. Deregulation of apoptosis is associated to tumor resistance to chemotherapeutic agents. Enhanced chemosensitivity of tumor cells is one of important therapeutic strategies for cancer therapy. This review will focus on biological characteristics and the structure of IAP proteins, and IAP-targeted therapies for cancer treatment. Key words: IAP; apoptosis; tumor; chemosensitivity cific IAL, Ts-IAP/hILP) IAP [2] (baculoviral IAP repeat containing ubiquitin conjugating enzyme, BRUCE/apollon) R oy [1 ] 8 IAPs 1995 IAP (neuronal apoptotic inhibi- 2009-07-31 2009-09-08 tor protein, NAIP) ( 3 0 4 2 8 0 1 1