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CRTER
解放军海军总医院
心内科,北京市
100037
高连如☆,女,解放军第二军医大学毕业,1996~2000年美国加利福尼亚大学旧金山心血管研究所博士后研究员,主任医师,主要从事心血管介入与干细胞治疗方面的研究。lianru@
国家“八六三”计划
(2006AA02Z469*
中图分类号:R394.2文献标识码:A
文章编号:1673-8225
(200746-09346-07
收稿日期:2007-07-16修回日期:2007-09-13(07-50-7-3852/ZS ?Y
Progress and mechanism of stem cell transplantation in the treatment of ischemic heart disease
Abstract
BACKGROUND:Despite the advanced therapeutic strategies of medical intervention and surgical procedures after myocardial infarction,which may improve coronary blood flow and salvage ischemic myocardium,is still not able to salvage necrosis or non-functional myocardium.Stem cells,as the material foundation of heart structures and function,have been proved to be one of safe and effective therapies for the improvement of cardiac function,although it is still extremely controversial.
OBJECTIVE:To summarize the clinical research progress on adult stem cells in treatment of ischemic heart disease,evaluate the safety and efficacy of adult stem cell therapy,speculate the mechanisms of adult stem cells on improving heart function,and introduce the future clinical study of adult stem cells.
RETRIEVE STRATEGY:English articles of adult stem cells and ischemic heart disease were searched in Pubmed databases published from 1996to 2007,with the key words adult stem cells,cardiomyocytes,ischemic heart disease.Meanwhile,a computer-based search was conducted in China Journal Full-text Database with the key words of adult stem cell,cardiomyocytes,ischemic heart diseasebetween 1996and 2007.Total 1303articles were selected firstly.Inclusive criteria:①The literatures were closely related to adult stem cell and ischemic heart disease.②The literatures of the same field were selected by the recent publication or the authority magazine publication.Exclusive criteria:①repetitive researches.②Meta analysis.
LITERATURE EVALUATION:The selected articles were mainly the reviews of the current status and mechanism of stem cell transplantation for ischemic he
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