mrna稳定性和细胞内定位.pptxVIP

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mrna稳定性和细胞内定位.pptx

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Chapter 22mRNA Stability and Localization;22.1 Introduction;FIGURE 01: Features of prokaryotic and eukaryotic mRNAs.;22.1 Introduction;22.2 Messenger RNAs Are Unstable Molecules;22.2 Messenger RNAs Are Unstable Molecules;FIGURE 03: Method for determining mRNA half-lives.;22.2 Messenger RNAs Are Unstable Molecules;22.3 Eukaryotic mRNAs Exist in the Form of mRNPs from Their Birth to Their Death ;FIGURE 04: The concept of an RNA regulon.;22.4 Prokaryotic mRNA Degradation Involves Multiple Enzymes ;22.4 Prokaryotic mRNA Degradation Involves Multiple Enzymes;22.4 Prokaryotic mRNA Degradation Involves Multiple Enzymes;22.4 Prokaryotic mRNA Degradation Involves Multiple Enzymes;22.5 Most Eukaryotic mRNA is Degraded via Two Deadenylation-Dependent Pathways ;22.5 Most Eukaryotic mRNA is Degraded via Two Deadenylation-Dependent Pathways;22.5 Most Eukaryotic mRNA is Degraded via Two Deadenylation-Dependent Pathways;22.5 Most Eukaryotic mRNA is Degraded via Two Deadenylation-Dependent Pathways;22.5 Most Eukaryotic mRNA is Degraded via Two Deadenylation-Dependent Pathways;22.6 Other Degradation Pathways Target Specific mRNAs ;FIGURE 08: Other decay pathways in eukaryotic cells;22.6 Other Degradation Pathways Target Specific mRNAs;22.6 Other Degradation Pathways Target Specific mRNAs;22.7 mRNA-Specific Half-Lives Are Controlled by Sequences or Structures within the mRNA ;FIGURE 10: Mechanisms by which destabilizing elements (DEs) and stabilizing elements (SEs) function;22.7 mRNA-Specific Half-Lives Are Controlled by Sequences or Structures within the mRNA;22.7 mRNA-Specific Half-Lives Are Controlled by Sequences or Structures within the mRNA;FIGURE 11: Regulation of transferring mRNA stability by iron levels;22.8 Newly Synthesized RNAs Are Checked for Defects via a Nuclear Surveillance System ;22.8 Newly Synthesized RNAs Are Checked for Defects via a Nuclear Surveillance System;FIGURE 12: The role of TRAMP and the exosome in degrading aberrant nuclear RNAs