抗血小板抵抗潜在的风险因素.pptxVIP

Is Antiplatelet Resistance a Potential Risk Factor?C.Richard Conti M.D. MACCThromboxane A2 is synthesized and released by human platelets in response to a variety of stimuli (collagen, thrombin, ADP, PAF) and amplifies platelet aggregation ADPclopidogrel bisulfateADPReoPro, Integrilin, AggrastatADPCollagenThrombinTXA2ActivationGpIIb/IIIaCOXTXA2aspirinADP = adenosine diphosphate, TXA2 = thromboxane A2, COX = cyclooxygenase.Schafer AI. Am J Med. 1996;101:199–209.Antiplatelet Agents:Mechanism of Action Is Aspirin resistance a Risk Factor?Aspirin is an effective antiplatelet agent with proven bene