糖尿病的治疗pt.pptxVIP

糖尿病治疗一、糖尿病药物治疗二、糖尿病慢性并发症的药物治疗三、糖尿病治疗新策略---手术治疗一、糖尿病的药物治疗Year100515-10-52型糖尿病的发展过程Insulin resistanceInsulin secretionMicrovascular ComplicationsMacrovascular ComplicationsPre-diabetesType 2 DiabetesOnsetDiagnosisPlasma GlucoseBrainLiverInsulin-Independent Glucose Uptake胰岛素抵抗与胰岛细胞功能紊乱GlucagonInsulinFatInsulinInsulin-dependent Glucose UptakePancreasSkeletal Muscle?-glucosidase inhibitors BrainLiver糖尿病药物治疗作用靶点MetforminTZDInsulinGLP-1Plasma GlucoseFatSulfonylureas GlinidesGLP-1Skeletal MuscleMetforminTZDInsulinPancreas磺脲类 相继问世一代、二代磺脲类双胍类α- 糖苷酶抑制剂餐时血糖调节剂 瑞格列奈噻唑烷二酮类餐时血糖调节剂 那格列奈GLP-1类似