长QT综合征抗心律失常药物.pptVIP

Acquired Long QT Syndrome by Antiarrhythmic Drugs;;;;;GENETIC FACTOR CONGENITAL ACQUIRED LONG QT SYNDROME LONG QT SYNDROME ( FORME FRUSTE ) - IT SHOULD BE REMEMBERED THE LOW PENETRANCE OF GENETIC DISORDERS - BETWEEN ENVIRONMENTAL FACTORS THE MOST IMPORTANT SEEMS TO BE THE CONCOMITANT HYPOKALEMIA;Genetic characterization of congenital LQT syndrome;Mechanims of Drug-induced QT Prolongation and TdP 1;Mechanims of Drug-induced QT Prolongation and TdP 2;Mechanims of Drug-induced QT Prolongation and TdP 3;Torsades de Pointes;Factors Modulate the Effects of Drugs That Block IKr;Part 1: Cardiac Drugs able to induce QT Prolongation and TdP;Class ? Antiarrhythmics;Li Kui: rude and rush by nature. Quinidine;Class III Antiarrhythmic Drugs 1;Bao Zheng: a clean political career and a man of justice. Sotalol;Drug induced TDP: comparison between Quinidine and Sotalol;Class III Antiarrhythmic Drugs 2;Meng Liang: a good general. Amiodaron;d- Sotalol Ibutilide Azimilide Tedisamil Ersentilide Dofetilide Dronedarone Almokalant;;;;;;Part 2: Acquired Long QT Syndrome by Non- Antiarrhythmic Drugs;;Part 3 Drug – Drug Interaction;Cytochrome P450(CYP) enzymes are divided into two classes on the basis of the fundamental characteristics of their substrates;;Part 4 How to Avoid Drug-Induced Torsades de Pointes;;;;;Flow chart for Sotalol administration ;Conclusions 1;Conclusions 2;Conclusions 3;THANK YOU;;docin/sanshengshiyuan doc88/sanshenglu