α-烯酰基二硫缩烯酮论文α-烯酰基二硫缩烯酮的合成与应用研究.docVIP

α-烯酰基二硫缩烯酮论文：α-烯酰基二硫缩烯酮的合成与应用研究 【中文摘要】多取代吡啶酮类化合物是重要的医药和有机合成中间体,在功能性化合物合成和药物合成中受到人们广泛的关注。多取代吡啶酮类化合物具有很强的生理活性,可作为活性化合物用于制药,如抗纤维化、抗肿瘤和治疗帕金森氏症等药物。α-羰基二硫缩烯酮相关化学经过多年的发展,在有机合成化学中占有了重要一席。本论文以α-烯酰基二硫缩烯酮为底物,通过成环策略、路易斯酸催化分子内成环反应,合成了系列吡啶酮类化合物,并建立了其合成方法。我们的工作以α-烯酰基二硫缩烯酮的合成为工作基础,发展新型合成方法,创建通用性强、步骤简洁的新型吡啶酮类化合物的合成新方法。为该类化合物在药物化学中的应用奠定了基础。 【英文摘要】Synthesis of heterocyclics have been extensively investigated as medicine and versatile intermediates in the synthesis of multi-functional complex molecules and natural products. N-Substituted pyridone compounds have versatile physiological activity. For instance, they can sterilize, ease pain, resist tumour and cure parkinsonism and so on. These compounds have powerful ability to form coordination compounds, which can cureβ-thalassemia beyond compare. The ramification of N-Substituted pyridone can be made to drug precursors.a-oxo ketene-S,S-acetals has taken an important place in the field of organic synthesis through many years hardwork by scientists. This article based on the a-enoyl ketene-S,S-acetals. Through Schiff-base strategy and Lewis acid catalytic annelation reaction, we synthesized a series of p yridone compounds and found out its synthesis method. This new method established a new synthesis way of pyridone compounds, which had extensive universal property and brief step. What’s more, this method had established a foundation for the compounds in the same category in the use of the pharmaceutical chemistry. 【关键词】α-烯酰基二硫缩烯酮 吡啶酮 六元环分子 【英文关键词】α-Allyl Ketene Dithioacetals Pyridone Six-Membered Ring Molecules 【目录】α-烯酰基二硫缩烯酮的合成与应用研究 摘要 4-5 ABSTRACT 5 目录 6-8 第一章 前言 8-30 1.1 α-羰基二硫缩烯酮类化合物简介 8-29 1.1.1 α-羰基二硫缩烯酮的结构 8 1.1.2 α-羰基二硫缩烯酮的制备 8-11 1.1.3 α-羰基二硫缩烯酮的反应研究 11-21 1.1.4 二硫缩烯酮在有机合成中的应用进展 21-29 1.2 选题意义、目的和研究策略 29-30 第二章 多取代吡啶-4(1H)酮的合成 30-41 2.1 引言 30-31 2.2 仪器与试剂 31-32 2.2.1 仪器 31 2.2.2 试剂 31-32 2.3 实验部分 32-36 2.3.1 α-羰基二硫缩烯酮类化合物的制备 32-33 2.3.2 α-羰基二硫缩烯酮与DMFDMA的