糖尿病与胰腺癌关系的探讨.pdfVIP

DOC格式论文，方便您的复制修改删减 糖尿病与胰腺癌关系的探讨 （作者:___________单位: ___________邮编: ___________） 作者：李军辉，沙焕臣，马清涌，王连才，郭坤，刘 晗， 黎韡 【摘要】目的探讨糖尿病与胰腺癌的关系，高血糖对胰腺癌组织内 神经的影响。方法 采用病例对照研究对我院1999 年1 月至2008 年 3 月诊治的胰腺癌患者513 例进行回顾性研究，分为血糖升高组和正 常血糖组，进行各项指标比较;并对手术切除组织标本进行神经相关 指标免疫组化染色，观察其表达差异。结果 各项指标中，高血糖组 更容易出现精神差(P0.05);有糖尿病史的患者中，血糖得到控制的手 术切除率和疼痛出现率明显增高(P0.05);免疫组化表现，两组亦有差 异。结论 明确有糖尿病史的胰腺癌患者，积极控制血糖有利于提高 根治性手术率，高血糖可使胰腺癌神经发生改变，可能参与了神经浸 润的发生。 【关键词】胰腺癌;糖尿病;神经浸润 ABSTRACT: Objective To explore the relationship between diabetes and pancreatic cancer and the role of hyperglycemia in the nerves distributed in pancreatic cancer. Methods We made DOC格式论文，方便您的复制修改删减 a retrospective case control study of 513 pancreatic cancer patients in our hospital between January 1999 and March 2008. They were divided into euglycemia group and hyperglycaemia group, and various indexes were compared between them. Expressions of protein gene product 9.5 (PGP9.5) and myelin P0 protein (MPP) were analyzed by immunohistochemistry in formalin fixed radical cured pancreatic cancer specimens from 81 pancreatic cancer cases and 10 normal pancreas tissue cases as controls. Results More cases had the symptom of weariness in hyperglycaemia group compared wit euglycemia group (P0.05). The frequency of radical operation and pain was higher when the level of blood glucose was controlled within the normal range in the cases wit the history of diabetes mellitus (DM) (P0.05). The frequency of strong PGP9.5 staining was significantly higher in hyperglycaemia group than in euglycemia group and normal control group (P0.05)whereas the expression of MPP was the opposite among the three groups (P0.05). Conclusion Controlling blood glucose within the normal level can help increase the rate of radical operation in pancreatic cancer cases with hyperglycaemia. Hyperglycemia can alter the nerve fibers i