2019年3线粒体基因组.pptVIP

mt DNA and human disease ? Recent research has demonstrated that several human diseases are caused by mitochondrial defects, and in some cases, these defects are due to mutations in the mtDNA. ? One such disease is Lebers hereditary optic neuropathy (LHON), a condition characterized by the sudden onset of blindness in adults. This disease is associated with the death of the optic nerve (at a physiological level), and with mutation in any of several mitochondrial genes (at a molecular level). Each mutation changes an amino acid in one of the mi