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In the early 1980s newly introduced
antiarrhythmics were found to be highly
successful at suppressing arrhythmias.
20世纪80年代早期,新引进的抗心律失常药被发现
在抑制心律失常方面很有效
Not until a RCT was performed was it
realized that, although these drugs suppressed
arrhythmias, they actually increased
mortality.
直到开展了临床随机对照试验,人们才意识到虽然
这些药物抑制了患者的心律失常,但增加了死亡率
1
Table 1 Cause of death and cardiac arrest (with resuscitation) in the CAST
Encainide group Flecainide group Both groups
Cause Total
Active drug Placebo Active drug Placebo Active drug Placebo
Patients in group 432 425 323 318 755 743 1498
All deaths and cardiac arrests 44 19 19 7 63 26* 89
Cardiac death or cardiac arrest 42 15 18 6 60 21* 81
Arrest with resuscitation 5 1 2 0 7 1 8
Death or arrest due to
29 12 14 4 43 16* 59
arrhythmia
Arrest with resuscitation 3 1 2 0 5 1 6
Death or arrest not due to
13 3 4 2 17 # 22
arrhythmia
Arrest with resuscitation 2 0 0 0 2 0 2
Noncardiac death 2 4 1 1 3 8
#
*P0.01, P0.05
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