囊性肾肿瘤诊断和鉴别诊断.ppt

Ten of 12 TC-RCCs had a chromosome 7 gain, 8 of 12 cases had a chromosome 17 gain, and 8 of 9 cases had a loss of Y chromosome. Six of 9 cases with all 3 chromosomes studied had a gain of chromosomes 7 and 17 and a loss of Y chromosome Zhou M, et al. Am J Surg Pathol 2009 Tubulocystic RCC with bone metastasis Human Pathology 2014 Tubulocystic RCC with PD foci Al-Hussain TO, et al. Hum Pathol 2014 Tubulocystic RCC with PD foci Al-Hussain TO, et al. Hum Pathol 2014 Tubulocystic RCC with PD foci Al-Hussain TO, et al. Hum Pathol 2014 Tubulocystic Renal Cell Carcinoma Composed of multiple thin-walled cysts line by hobnail cells. Considered as a new entity in ISUP 2012 Classification. Seemed to be a low grade RCC, may demonstrated PD foci or sarcomatoid differentiation with increased risk for recurrence and metastasis. Classification of RCCs with Promnient Cystic Change All RCCs can display cystic change macro- or micro-scopically. Molecular events such as VHL mutation in CCRCC Local ischemia, necrosis, degeneration with compensatory ectasia Multilocular cystic renal cell tumor with low malignant potential / Multilocular cystic RCC Clear cell RCC with extensive cystic change Tubulocystic RCC APKD-associated RCC Multilocular oncocytoma Multilocular Cystic RCC ISUP 2012: Redesignation of multilocular cystic RCC as multilocular cystic renal cell neoplasms of low malignant potential Cystic Partially Regressed CCRCC Williamson SR, etal. Histopathology 2013 Acquired Cystic Disease Associated Renal Cell Carcinoma(ACD-RCC) Pan CC, et al. Histopathology, 2009; 55: 145-153 Acquired Cystic Disease Associated Renal Cell Carcinoma(ACD-RCC) Acquired Cystic Disease Associated Renal Cell Carcinoma(ACD-RCC) ACD-RCC Multilocular Oncocytoma Telangiectatic Oncocytoma Approaches to Diagnosis of Cystic RCCs Cysts lined by clear cell Yes No Solid acinar and glandular pattern No Multilocular cystic RCC Yes Papilla arising from cyst CCPRCC CCRCC Eosinophilic cells