药物溶液与塑料包装材料聚丙烯及其他材料相容性.pdfVIP

International Journal of Pharmaceutics 185 (1999) 113–121 locatepromis Compatibility of plastics with cytotoxic drug solutions—comparison of polyethylene with other container materials C. Beitz a,*, T. Bertsch b, D. Hannak b, W. Schrammel c, C. Einberger a, M. Wehling d a Hospital Pharmacy, Klinikum Mannheim gGmbH, Fakulta¨t fu¨r Klinische Medizin Mannheim der Uniersita¨t Heidelberg, Theodor-Kutzer - Ufer 1– 3, 68135 Mannheim, Germany b Institute of Clinical Chemistry, Klinikum Mannheim gGmbH, Fakulta¨t fu¨r Klinische Medizin Mannheim der Uniersita¨t Heidelberg, Theodor-Kutzer - Ufer 1– 3, 68135 Mannheim, Germany c B. Braun Melsungen AG, Germany d Institute of Clinical Pharmacology, Klinikum Mannheim gGmbH, Fakulta¨t fu¨r Klinische Medizin Mannheim der Uniersita¨t Heidelberg, Theodor-Kutzer - Ufer 1– 3, 68135 Mannheim, Germany Received 25 January 1999; received in revised form 4 May 1999; accepted 6 May 1999 Abstract In this study low density polyethylene (LDPE)-containers were compared to glass bottles and polyvinyl chloride (PVC) bags in view of adsorption effects with antineoplastic drugs. The infusion containers were supplemented with therapeutic doses of the nine common cytotoxic drugs carboplatin, carmustine, cytarabine, dacarbazine, fluorouracil, gemcitabine, melphalan, methotrexate and vinorelbine. 0.9% isotonic sodium chloride solution and 5% dextrose served as inf