2018-JNP-中南民大刘吉开-Irpeksins A−E.pdfVIP

Article Cite This: J. Nat. Prod. XXXX, XXX, XXX−XXX pubs.acs.org/jnp Irpeksins A−E, 1,10-seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity Yang Tang,‡, § Zhen-Zhu Zhao,‡ Jian-Neng Yao, ‡, § Tao Feng,† Zheng-Hui Li,† He-Ping Chen,*,† and Ji-Kai Liu*,† †School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People’s Republic of China ‡State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China . § ) University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China C T s. U e l ( S c *Supporting Information 8 i t 3 r : a 1 1 d : e 6 h ABSTRACT: Five new triterpenoids, irpeksins A−E ( 1−5), 0 s i t l a b were isolated from fruiting bodies of the medicinal fungus u 8 p 1 e Irpex lacteus. The structures as well as absolute configurations 0 2 r a 9, h of the new compounds were established via extensive spectro- s 1 y scopic analysis, computational methods, and Cotton effects. r l e e b t o a Compounds 1−4 are featured by a scaffold of 1,10-seco- and t m c i t ring B aromatic eburicane (24-methyllanostane), and com- O i g n e o l pound 5 is character