口腔生物学：2012级口腔生物学总论.pptVIP

口腔生物膜疾病与微生物的关系 结核杆菌的发现者 1905年获得诺贝尔医学和生理学奖 提出“科赫原则” Robert Koch Koch 原则 The microbe should be found in all cases of the disease. 所有病例里均发现致病菌。 The microbe should be grown on laboratory media for several subcultures. 致病菌可体外培养。 A pure subculture should produce the disease in a susceptible animal. 在动物体内引入致病菌，可致病。 A high antibody titre to the microbe should be detected during infection. 可诱导抗体产生 特异性菌斑学说 (Specific Plaque Hypothesis) 非特异性菌斑学说 (Non-Specific Plaque Hypothesis) 生态菌斑学说 (Ecological Plaque Hypothesis) Disease is a result of a shift in the balance of the resident microflora due to a respons