急性细菌性鼻窦炎及抗生素选择[参考].pptVIP

氟喹喏酮对肺炎链球菌肺炎的药效学比较 抗菌活性 PK* 杀菌能力 [游离药] [游离药] 相对杀菌 抗生素 (MIC90) (24 h AUC) (AUC/MIC) 能力 左氧氟沙星 500 mg 2 33.3 16.7 1.0X 左氧氟沙星 750mg 2 70.7 35.4 2.0X 加替沙星 400 mg 0.5 26.8 53.6 3.2X 莫西沙星 400 mg 0.25 24.0 96 5.7X * Based on prescribing information on the following dosages: levofloxacin, 500 mg po QD and 750 mg po QD, gatifloxacin, 400 mg po QD, and moxifloxacin, 400 mg po QD. Levels represent free unbound drug, and were determined in volunteers with normal renal function; protein binding: levofloxacin: 30%, gatifloxacin 20%, and moxifloxacin 50%. Ball P. History and Overview. In: Andride VT, ed