病理学教学课件：肿瘤2.pptVIP

Oncogene products are links in signal chains that stretch from the cell surface to the genetic material in the cell nucleus. This chain is composed of (1) growth factors, (2) growth factor receptors, (3) signal transducing proteins in cell membranes, (4) phosphokinases in the cytoplasm and (5) proteins transported from the cytoplasm into the nucleus where they bind to DNA. The localization of different oncogene products (Sis, ErbB, Ras, Src, Myc) is schematically indicated. encode proteins that inhibit cellular proliferation by regulating the cell cycle. RB gene (retinoblastoma gene) P53 gen