有机化学学术报告示例两个丙烯酸酯间立体选择性交叉耦合一个合成粘糠酸衍生物有效途径.pptVIP

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有机化学学术报告示例两个丙烯酸酯间立体选择性交叉耦合一个合成粘糠酸衍生物有效途径.ppt

Stereo-and Chemoselective Cross-Coupling between Two Electron Deficient Acrylates An Efficient Route to(Z, E)-Muconate Derivatives Hu, X.H; Zhang, C; Yang, X.-F, Xu Y.H.; Loh, T-P Am. chem. Soc. 2016. 137. 3169-3172 Oral-report by Li-Hua Zhu, He-Yang Wei, Pe‰u Autho Teck-Peng Loh His central theme is organic synthesis. Research activities include green chemistry, asymmetric synthesis, the development of new synthetic methodology, and total synthesis of architecturally complex organic molecules with interesting biological activities. One of the objectives is to develop new c-c bond formation reactions with predictable control of stereochemistry under very mild and environmentally friendly conditions and then apply them to the synthesis of complex natural products. Another objective is to discover new reactions and concepts through the total synthesis of natural products Autho Teck-Peng Loh Academic Career History 1989-1990 Teaching Assistant, Harvard University Extension School, USA 1990-1991 Teaching assistant, harvard University USA 1994-1999 Lecturer, Senior Lecturer (Assistant Professor), Department of Chemistry, National University of Singapore(NUS) 1999-2004 Associate Professor, Department of Chemistry, National University Singapore(NUS) .002-2003 Visiting Professor, Columbia medical school, Columbia University, 2002 to now Adjunct Professor, Soo Chow University, China 2004-2005 Professor, Department of Chemistry, National University of Singapo (NUS) 2005 to now Professor, Division of Chemistry Biological Chemistry, School of Abstrac A Ru-catalyzed direct oxidative crosscoupling reaction of acrylates was developed. It offers a straightforward and atom-economical protocol for the synthesis of functionalized (Z, E)-muconate derivatives in moderate to good yields with good stereo-and chemoselectivities The conjugated muconates bearing differentiable terminal functionality can be selectively transformed into versatil

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