噶米W1106401组织因子及组织因子途径抑制物在急性脑血管意外修改1.docxVIP

组织因子及组织因子途径抑制物在急性脑血管意外并发神经源性肺水肿中的变化研究 [摘要]目的：探讨急性脑血管意外并发神经源性肺水肿（ NPE中组织因子（TF）及其抑制物（TFPI）在的变化情况。 方法：选择本院2007年6月一2010年5月收治的急性脑血管意外患者 80例为研究组，其中脑出血 30例，脑梗死50 例，选择同期健康体检者 40例为对照组，分别采用酶联免疫吸附抗原法检测患者血浆 TF、TFPI,并进行组间比较。结 果：研究组患者血 TF值均高于对照组，研究组中，脑出血患者血 TFPI高于对照组，脑梗死患者血 TFPI低于对照组， 差异具有统计学意义（P0.05）。脑出血及脑梗死患者中，并发神经源性肺水肿的患者，血 TF、TFPI均高于未并发的 神经源性脑水肿患者，差异有统计学意义， （P0.05 ）。结论：急性脑血管意外并发神经源性肺水肿的发生与凝血异常、 炎症反应有关，组织因子及组织因子抑制物可能参与了肺损伤发生发展的过程。 [关键词]急性脑血管意外，神经源性肺水肿；组织因子；组织因子途径抑制物 Changes of tissue factor and tissue factor pathway inhibitor in acute cerebral vascular accident complicated neurogenic pulmonary edema [Abstract] Objective: To investigate the changes of tissue factor （TF）and tissue factor pathway inhibitor（TFPI） in acute cerebral vascular accident complicated neurogenic pulmonary edema . Methods: 80 patients with acute cerebral vascular accident of which 30 cases of cerebral hemorrhage, 50 cases of cerebral infarction in our hospital from June 2007 to May 2010 were selected as study group, 40 cases of healthy in the same period were chosen as control group. TF, TFPI were detected by ELISA technique and the results were compaired. Results: TF levelof study group wwas higher than control group; in study group, TFPI of patients with cerebral hemorrhage was higher than control group, but TFPI of patients with cerebral infarction was lower than control group, the difference was statistically significant （P0.05）; the levels of TF, TFPI of patients with neurogenic pulmonary edema were all higher than patients with no that,the difference was statistically significant （P 0.05）. Conclusion: The occurrence of neurogenic pulmonary edema inpatients wuth acute cerebrovascular accident is relevant with coagulation abnormalities, inflammatory response; TF and TFPI may be involved in the development of lung injury process. [Key words] Ccute cerebral vascular accident, Neurogenic pulmonary edema; Tissue factor; Tissue factor pathway inhibitor 神经源性肺水肿（NPE是指在无原发性心、肺和肾等疾病的情况下，由颅脑损伤或中枢神经系统（ CNS其他疾 病引