神经精神药理英文课件：DRUGS OF ABUSE.pptVIP

Marihuana (Cannabis) High lipid solubility but does not dissolve well in water so if taken orally they are absorbed through the digestive system rather slowly. Smoking causes 50% of cannabinoids to enter the lungs. Holding the smoke in the lungs maximizes absorption. Cannabis B. Mechanism of Action In 1990 the THC receptor was cloned and in 1992 the endogenous cannabimimetic was discovered. They named it anandamide (ànanda, in Sanskrit = bliss). Anandamide is the ethanolamine of arachidonic acid. Cannabinoids as well as anandamide inhibit Adenylate Cyclase (which produces cAMP) both in brai