卡维地洛纳米混悬渗透泵给药系统的研究.pdf

LOGO 卡维地洛纳米混悬渗透泵给药系统的研究 Research of  Carvedilol  Nanosuspension Osmotic  Pump Drug Delivery  System  Shenyang Pharmaceutical University Pan Weisan Contents 1 Introduction Introduction Fabrication and evaluation of Fabrication and evaluation of 2 carvedilol nanosuspension carvedilol nanosuspension Preparation of osmotic pump Preparation of osmotic pump 3 capsule filled with nanosuspension capsule filled with nanosuspension Summary 4 Summary 1 Section I Section I Introduction Ø To improve Solubility and dissolution rate of Ø To improve Solubility and dissolution rate of water insoluble drugs, it is imminently need to water insoluble drugs, it is imminently need to develop new pharmaceutical technology and new develop new pharmaceutical technology and new dosage forms. dosage forms. ü drug nanosuspensionsnew technology ü drug nanosuspensionsnew technology ü osmotic pumpnew formulation strategy ü osmotic pumpnew formulation strategy l 申请的 l 申请的 中国发 中国发 明专利 明专利 今年获 今年获 得授权 得授权 2 Section I Section I Introduction Ostwald Freundlich Ostwald Freundlich Noyes－Whitney Noyes－Whitney Solubility ～particle size Solubility ～particle size Dissolution rate ～particle size Dissolution rate ～particle size Particle size r↓ Particle size r↓