biCK 预防疫苗的安全性和有效性的评价.pptVIP

Safety and Efficacy Evaluation of Preventive Vaccines Cynthia Kleppinger, M.D. Center for Biologics Evaluation and Research Food and Drug Administration December 7, 2000 Preventive Vaccines Preparation containing a modified pathogen to induce an immune response to protect against an infectious disease Given largely to healthy individuals Among the most powerful tools for disease prevention Two Immune Systems Innate-first line of defense, non-specific, phagocytic cells Adaptive-specific, memory, lymphocytes Vaccination Relies primarily upon the adaptive immune system Types of Vaccines Live