芳酰基脲及硫脲类化合物的绿色合成与研究.docVIP

Y 1132379 密级- 分类_ 硕士学位论文 芳酷基服及硫脲类化合物的绿色合成与研究 宋爱英 指导教师姓名： 申请学位级别： 论文提交日期： 论文答辩日期： 学位授予单位： 王喜存教授 理学硕士 2007年5月 2007年5月 西北师范大学 专业名称：有机化学 研究方向：精细有机合成 学位授予日期：2007年6月 答辩委员会主席: 评阅人： 二零零七年五月 Abstract Environmentally friendly chemical process is the vital part of the current chemical research and development. Organic reactions in water media and carried out via grinding have attracted more and more attention torn chemists because they have many potential advantages and benefits in terms of cost, safety, environmental concerns, efficiency, and selectivity, Memiwhilc, above methods are practical and worthwhile because of simple reaction conditions and high reaction rates. Ureas and thioureas are u^ widely such as: applications as dyes, antioxidants, pesticides, conosion inhibitors，intennediates for the preparation of phamiaceuticats, and agricultural chemicals. Recently, in order to get better active compounds, chemistry and medicine researchers are doing further research on them. This thesis mainly introduced that ureas and semicaitnizides were synthesized by oxidation of coTf^sponding thioureas and thiosemicaibazides using 30% peroxide as oxidant In addition, we further discussed about reaction conditions for synthesizing isothiocyanide in aqueous media. And based on the above reaction conditions, some related thioureas were prepared successfully in high yields. This thesis contains four chapters, they are: Chapter 1: Some of oiganic reactions in aqueous and by grinding were reviewed in this chapter. Compared with traditional methods, they are environmental, rapid, high yields, simple work-up and so on. Chapter 2 aad 4: ureas/semicarbazides were synthesized using 30% peroxide hydrogen as oxidant. Compared with the tiaditionat methods, our procedures have advantages of high reaction rates, excellent yields，benign to environment and simple work-up procedure. Chapters 3: Wc synthesized important intermediate in water used acyl chloride, ammaniiim tbiocyanate and TEBA as starting