人和小鼠shRNA文库.docVIP

PAGE PAGE 1 shRNA文库：RNA干扰研究者的福音 Nature 428, 427 - 431 (25 March 2004); doi:10.1038/nature02370 A resource for large-scale RNA-interference-based screens in mammals PATRICK?J.?PADDISON1,*, JOSE?M.?SILVA1,*, DOUGLAS?S.?CONKLIN1,*,?, MIKE?SCHLABACH2,?, MAMIE?LI2, SHOLA?ARULEBA1, VIVEKANAND?BALIJA1, ANDY?OSHAUGHNESSY1, LIDIA?GNOJ1, KIM?SCOBIE1, KENNETH?CHANG1, THOMAS?WESTBROOK2,?, MICHELE?CLEARY3, RAVI?SACHIDANANDAM1, W.?RICHARD?MCCOMBIE1, STEPHEN?J.?ELLEDGE2,? GREGORY?J.?HANNON1 1?Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New