疏肝健脾养阴方联合内分泌治疗激素依赖型乳腺癌的临床研究.doc

疏肝健脾养阴方联合内分泌治疗激素依赖型乳腺癌的临床研究 ［摘耍］目的探讨疏肝健脾养阴方联合内分泌治疗在激素依赖型乳 腺癌中的作用和价值。方法 将2010年7月?2012年12月在浙江省中医 院或湖州市妇幼保健院治疗的136例患者分为四组：A组(绝经前，中药 联合内分泌治疗，43例)，B组(绝经前，单纯内分泌治疗，30例)，C组 (绝经后，中药联合内分泌治疗，36例)及D组(绝经后，单纯内分泌治 疗，27例),随访记录相关指标,采用SPSS 17.0进行统计分析。结果A、 C组CA153、T抑制(CD3+/CD8+)、总胆固醇(CH0L)、谷氨酰转肽酶(GGT) 及纤维蛋白原(FIB)均分别低于B、D组，T辅助/T抑制(CD4+/CD8+) 分别高于氏D组，差异有统计学意义(卩〈0. 05)o结论中药联合内分 泌治疗激素依赖型乳腺癌，可提高临床疗效，减少毒副作用，值得临床进 一步推广。 ［关键词］中药；内分泌治疗；激索依赖型乳腺癌；作用机制 ［中图分类号］R737. 9 ［文献标识码］A ［文章编号］1673-7210 (2014) 08 (a) -0094-06 Clinical study of Soothing Liver and Strengthening Spleen and Tonifying Yin Herb plus endocrine-therapy for hormone-dependent breast cancer MA Yelinl CHEN Liangliang2 1.Department of TCM, Zhejiang Hospital, Zhejiang Province, Hangzhou 310013 , China : 2. Department of Medical Oncology , Zhejiang Hospital of TCM, Zhejiang Province, Hangzhou 310006, China [Abstract] Objective To explore the action of Soothing Liver and Strengthening Spleen and Tonifying Yin Herb plus endocrine-therapy and the significance in treatment of hormone-dependent breast cancer. Methods 136 patients who were treated in Zhejiang Hospital of TCM or Huzhou Maternity Child Care Hospital from July 2010 to December 2012 were divided into 4 groups： group A (premenopausal, herbs plus endoerine-therapy, n二43), group B ( premenopausal, endocrine-therapy, n=30 ), group C (postmenopausal, herbs plus endocrine-therapyn=36) and group D (postmenopausalr endocrine-therapy, n二27). Data was regi stered and analyzed by SPSS 17. 0. Results CA153, CD3+/CD8+, CHOL, GGT and FIB of group A and group C were significantly reduced, while CD4+/CD8+ was improved, compared with group B and group D (P 0. 05) . Conclusion Herbs plus endocrine-therapy can significantly improve the cl inical effects and al 1 eviate side-effects, which is worth of promotion in clinic? [Key words] Herbs ； Endocrine-therapy ； Ilormone-dependent breast cancer； Meehani sin 乳腺癌是女性最常见的恶性肿瘤之一，好发于40?60岁绝经前后的 妇女，在我国发病率仅次于胃癌和肺癌，居第三位［1］;美国国立癌症研 究所最新数据显示，乳腺癌居美国女性恶性肿瘤病死率第一位