序贯疗法与传统三联法根治幽门螺杆菌感染性十二指肠球部溃疡的临床效果及安全性分析.docVIP

序贯疗法与传统三联法根治幽门螺杆菌感染性十二指肠球部溃疡的临床效果及安全性分析 目的探究幽门螺旋杆菌（Hp）感染性「二指肠球部溃疡患者采取序贯疗法的临床效果及安 全性，并为该病最优化治疗积累临床经验。方法选取我院消化内科于2010年7月?2012年 10月收治的84例| ?二指肠球部溃疡患者，利用随机数字表法进行分组，分别设为研究组和 对照组，每组0 42例。其屮对照组开展传统三联疗法，研究组则实施序贯疗法，疗稈均为 4周。记录两组患者治疗前及治疗后第4周末溃疡愈合、腹痛缓解、Hp根除及不良事件发 生情况。结果两组干预前溃疡程度茅异无统计学意义（P0.05）；干预后，研究组溃疡处于 S1和S2期例数为19例，愈合率为45.2%,对照组处于S1和S2期例数为15例，愈合率为 35.7%,羌异有统计学意义（PvO.05）。两组干预前腹痛程度差异无统计学意义（P0.05）； 两组干预后的腹痛稈度均轻于干预前（PV0.05）；硏究组干预后的腹痛缓解情况优于对照组 （P0.05）o研究纟H.Hp完全清除为39例，清除率为92.9%,对照纟H. Hp完全清除为33例， 清除率为78.6%,差异有统计学意义（PvO.05）。研究纽?用药不良事件发生率为14.3%,对照 组为14.3%,差异无统计学意义（P0.05）,经对症处理后，不良事件均不影响患者药物的 后续服用。结论Hp感染性-| ?二指肠球部溃疡患者开展序贯疗法能有效根除Hp,促进溃疡 创血愈合，且安全性较佳，取得较为满意的临床成效。 关键词：序贯疗法；三联疗法；幽门螺旋杆菌；I二指肠溃疡 Analysis of the clinical effect and safety of duodenal ulcer with Helicobacter pylori radicalsequential therapy and conventional therapy Abstract: Objective To explore the Helicobacter pylori （Hp） infection in patients with duodenal ulcer the clinical effect and safety of sequential therapy for this disease, and optimal treatment of the accumulation of clinical experience. Methods 84 cases of patients with duodenal ulcer in Department of internal medicine in our hospital from 2010 July to digest ?2012 year in October, using the method of random digits table group, which were divided into study group and control group, each group had 42 cases. The control group received traditional triple therapy, study group will carry out the sequential therapy, treatment for 4 weeks. Record two groups of patients before and after treatment fourth weeks ulcer healing, pain, Hp eradication and adverse event. Results there were no significant differences in the degree of ulcer of two groups before intervention （P0.05）; intervention, ulcer research group in SI and S2 phase were 19 cases, the cure rate was 45.2%, control group in SI and S2 phase were 15 cases, the cure rate was 35.7%, the difference was statistically significant （P0.05）. The two groups had no statistically significant differences in the degree of interv