histocompatibilitycomplex(个主要组织相容性复合体).pptVIP

HLA-Ⅱmolecules Structure Heterodimers of α andβglycoprotein chains. Each chain has 2domains(α1, α2 and β1, β2) α1 and β1 form the binding groove. (the polymorphic region) CD4 bind to β2 domain 2. Cellular distribution class Ⅱmolecules are expressed on B cells Mφ Dendritic cells Vascular endothelial cells Functions Antigen processing and presenting (exogeneous pathway): both pathogens in cellular vesicles and those come from outside the cell are presented on MHC class Ⅱmolecules of APCs and are transported to the cell surface where they can be recognized by CD4 + T cell Involve in tra