出凝血功能的常用检测方法分析.pptVIP

The coagulation cascade. The extrinsic pathway is initiated by the release of tissue factor from plaque macrophages and other subendothelial elements. The fibrin generated in consequence stabilizes the platelet plug, which forms as a result of the exposure of subendothelial connective tissue. The tissue factor/VIIa complex can also activate Factor IX, leading to fibrin generation via the intrinsic coagulation pathway as well. 凝血通路分为内源和外源两部分。一般认为，冠状动脉血栓始自斑块破裂 - 组织因子释放 - 组织因子+因子7复合物形成，外源通路因而启动。 而后内源通路也被激活，血栓大量形成。 Tissue factor, released following plaque fissure or rupture, activates Factor VII