bindingsitesonnmdareceptor对nmda受体的结合位点.pptxVIP

General Features of LGICs;Superfamilies of Ligand-Gated Channels;Topologies for Ligand-Gated Ion Channels;Cys-Loop Channels;Topology of Cys-Loop Channels;nAChR Subunit Composition;nAChR: Single Channel Recording ;Structure of nAChR;Ion Selection: Cationic Channels;Model for nAChR Gating: Twisting of M2 Helices;Atomic-Resolution Structure of nAChR;GABA Receptor Subunit Composition;Ion Selection: Chloride Channels;GABA-R: Predicted Interaction Between Cys-Cys Loop and TM2-TM2 Linker;Gating of GABA Channels: InteractionBetween the Cys-Loop and the M2-M3 Linker ;Crosslinking of Substituted Cysteinesin M2-M3 Link and Signature Loop ;Benzodiazepines and Barbiturates EnhanceGABAA Currents Through Different Mechanisms;Ionotropic Glutamate Receptors;Topology of Glutamate Receptors;Ionotropic Glutamate Receptor Subunits;Ion Selectivity of Glutamate Channels;RNA Editing Determines Ca2+-Permeability of AMPA Receptors;RNA Editing DeterminesCa2+-Permeability of AMPA Receptors;Kinetics of Glutamate Channels;Isolating AMPA-R and NMDA-R CurrentsWith Selective Blockers;;NMDAR Current: Voltage-Dependent Block by Mg2+ ;Mg2+ Site;NMDA Receptors are ActivatedDuring Intense Synaptic Activity;NMDA Receptors Mediate Synaptic Ca2+ Entry;Synaptic Plasticity NMDA Receptors;Induction of NMDAR-Dependent LTP;LTP Requires a Transient NMDAR-Mediated Rise in Postsynaptic Ca2+;Cys-Loop Channels;Topology of Cys-Loop Channels;Structure of nAChR;Model for nAChR Gating: Twisting of M2 Helices;Kinetics of Glutamate Channels;Induction of NMDAR-Dependent LTP