谷歌ppt生物信息大数据life-sciences-overview.pptVIP

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2021-04-08 发布于北京
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谷歌ppt生物信息大数据life-sciences-overview.ppt

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Sequencing the start of most analysis People = Umanaged data Data in wrong place Duplicated Nobody can find anything Inc systems:Backups/security Capacity planning? * Big data and Life Sciences Guy Coates Wellcome Trust Sanger Institute gmpc@sanger.ac.uk The Sanger Institute Funded by Wellcome Trust. 2nd largest research charity in the world. ~700 employees. Based in Hinxton Genome Campus, Cambridge, UK. Large scale genomic research. Sequenced 1/3 of the human genome. (largest single contributor). Large scale sequencing with an impact on human and animal health. Data is freely available. Websites, ftp, direct database access, programmatic APIs. Some restrictions for potentially identifiable data. My team: Scientific computing systems architects. DNA Sequencing TCTTTATTTTAGCTGGACCAGACCAATTTTGAGGAAAGGATACAGACAGCGCCTG AAGGTATGTTCATGTACATTGTTTAGTTGAAGAGAGAAATTCATATTATTAATTA TGGTGGCTAATGCCTGTAATCCCAACTATTTGGGAGGCCAAGATGAGAGGATTGC ATAAAAAAGTTAGCTGGGAATGGTAGTGCATGCTTGTATTCCCAGCTACTCAGGAGGCTG TGCACTCCAGCTTGGGTGACACAG CAACCCTCTCTCTCTAAAAAAAAAAAAAAAAAGG AAATAATCAGTTTCCTAAGATTTTTTTCCTGAAAAATACACATTTGGTTTCA ATGAAGTAAATCG ATTTGCTTTCAAAACCTTTATATTTGAATACAAATGTACTCC 250 Million * 75-108 Base fragments ~1 TByte / day / machine Human Genome (3GBases) Economic Trends: Cost of sequencing halves every 12 months. Wrong side of Moores Law. The Human genome project: 13 years. 23 labs. $500 Million. A Human genome today: 3 days. 1 machine. $8,000. Trend will continue: $1000 genome is probable within 2 years. Informatics not included. The scary graph Peak Yearly capillary sequencing: 30 Gbase Current weekly sequencing: 7-10 Tbases Data doubling Time: 4-6 months. Gen III Sequencers this year? Pbytes! Sequencing data flow. Sequencer Processing/ QC Comparative analysis Archive Structured data (databases) Unstructured data (Flat files) Internet Alignments (200GB) Variation data (1GB) Feature (3MB) Raw data (10 TB) Sequence (500GB) A Sequencing C