【临床医学】佝偻病#x2d;2005(2).pptxVIP

Vitamin D deficiency儿 科 医 院徐 秀In the skin:Ultraviolet lightProvitamin D3foodsVitamin D3 (an inactive form)In theLiver:Hydroxylation25-hydroxy vitamin D3In the kidneys:Hydroxylation1, 25-hydroxy vitamin D, (active form)Vitamin D Synthesis and ActivationVitamin D rolesFacilitate intestinal absorption of calcium and phosphorusPromote renal reabsorption of phosphorusDirect effect on bone deposition and reabsorption of calcium and phosphorusMaintain calcium and phosphorus homeostasisKidneys+1,25(OH)2D+l,25(OH)2D-PTH4-PTH-CTBoneCa,PHomeostasisParathormone (PTH)^1,25(OH)2DCalcitonin(CT)1,25(OH)2DCa,