莫沙必利结合齐拉西酮治疗功能性消化不良伴抑郁的临床效果.docVIP

莫沙必利结合齐拉西酮治疗功能性消化不良伴抑郁的临床效果观察 杨凌玲 李继昌 马那琦 景艳艳 【作者工作单位】宝鸡市中心医院（宝鸡市，721008）。 【第一作者简介】杨凌玲（1980.7-），女，陕西安康人，本科，主治医师，研究方向：临床消化系统疾病诊治。 【通讯作者】杨凌玲（Email：bjszxyyyll@163.com）。 【摘要】目的：对莫沙必利结合齐拉西酮治疗功能性消化不良伴抑郁的临床效果进行研究和分析。方法：选取我院2014年7月~2015年7月收治的功能消化不良伴抑郁患者共90例，随机分成对照组45例，应用莫沙必利治疗；观察组45例，应用莫沙必利结合齐拉西酮共同治疗。治疗5周后，对症状的消退情况进行观察比较。结果：治疗前两组患者的HAMD评分以及各症状积分差异无统计学意义，治疗后，观察组患者HAMD评分（2.1±0.2）分低于对照组HAMD评分（2.9±0.5）分，患者各症状积分均优于对照组，观察组的总有效率高达88.89%高于对照组的总有效率77.78%，组间比较，P＜0.05。结论：应用莫沙必利结合齐拉西酮对功能性消化不良伴抑郁患者进行治疗，有着较好的临床效果，副作用非常的小，安全性非常的高，可以在临床上推广应用。 【关键词】莫沙必利；其拉西酮；功能性消化不良；抑郁；临床观察 Mosapride combined with ziprasidone in the treatment of functional dyspepsia clinical observation of adverse effects associated with depression,Yang Lingling，Li Jichang，Ma Naqi，et al.Baoji Central Hospital, Shaanxi Province,Baoji 721008,china [Abstract] Objective:To citrate mosapride combined with ziprasidone in the treatment of functional digestive adverse accompanied with depression and the clinical effect of research and analysis. Methods: selected in our hospital in 2014 July 2015 years 7 months were functional dyspepsia with depression in patients with a total of 90 patients randomly divided into control group (n = 45), mosapride will facilitate the treatment; observation group (45 cases), mosapride will benefit combined with ziprasidone treatment. After 5 weeks of treatment, the symptoms were observed and compared. Results: there was no significant difference in HAMD scores and symptom scores between the two groups before treatment, after treatment, the HAMD score of the observation group was significantly lower than that of the control group (0.2 0.5). The total effective rate of the observation group was 88.89% higher than that of the control group, the total effective rate was 77.78%, P 0.05. Conclusion: the application of Mosapride will benefit combined with Ziprasidone on digestive function of dysplasia of the depressive patients were treated with good clinical effect, side effects are very small, security i