药理学教学课件：Drugs for the Treatment of Degenerative Disease in Central Nervous System.ppt

Drugs for treating AD Senile Dementia：Include primary （Also called Alzheimer’s disease, AD）and vascular dementia （VD）. Senile Dementia is a kind of disturbance of intelligence induced by organic brain damage. The main representations of the desease are the loss of ability about memory、judgment and abstract thinking. Incidence ： AD account for 70% of senile dementia. There are about 5% patients amang 65y adults ，but ＞90% amang 95y adults. The course of AD disease last whin 3-20 years. Patients can survive for 10 years in avarage after absolutely diagnosis. The spirit die first and then the flesh. Pathological Change： A. Amyloid protein(AP) deposition out of the cells Related to the variation of AP Precursor B. Fiber Tangle in neuron C. Senile Spot Anatomical Features： Cerebral shrinkage （hippocampus and the forebrain） Functional Features： Transmission impairment of cholinergic nerve excitation ; degeneration of Ach R in CNS and reduction of the neuron number. Treating Methods is lie on improving the symptoms mainly. Inhibiting drugs of Ach-E; Stimulant of Cerebral metabolism; Drugs for improving cerebral micro-circle; Calcium antagonists 老年斑（SP） Alzheimer’s disease is a progressive brain disorder that gradually destroys a person’s memory and ability to learn, reason, make judgments, communicate and carry out daily activities. As Alzheimer’s progresses, individuals may also experience changes in personality and behavior, such as anxiety, suspiciousness , as well as hallucinations or delusions. Although there is currently no cure for Alzheimer’s, effective care and support can improve quality of life for individuals. I Inhibiting Drugs of Ach-E Tacrine Product of first generation.May delay the course of disease for 1－12 month. 【The In Vivo Process】 A Medication by P.O. or injection. B Absorption is influenced by foo