印度昌迪加尔市微生物技术研究所生物信息学课件1.pptxVIP

;Hierarchy in Biology Atoms Molecules Macromolecules Organelles Cells Tissues Organs Organ Systems Individual Organisms Populations Communities Ecosystems Biosphere;Cells and DNA;Animal cell;Human Chromosomes;Chromosomes and DNA;Genome Annotation;WHOLE GENOME SEQUENCING ;Genome annotation tools at IMTECH;Genome assembly and annotation done at IMTECH;Concept of Drug and Vaccine; ;Antibiotics and drug resistance;Drug Discovery and Design ;Drug Discovery and Design;Techology is impacting this process;Drug Design based on Bioinformatics Tools;Important Points in Drug Design based on Bioinformatics Tools;The amount of fund required depends on the success rate at the clinical trial stage;An overview of the workflow of in silico drug designing process;;Examples of open source software;Challenges in Drug Discovery ;;;Understanding Immune System;.;Human Vaccines against pathogens;History of Immunization;Concept of vaccine and Drug Drug: Kill invaders/pathogens and/or Inhibit the growth of pathogens Vaccine: Trained immune system to face various existing disease agents Type of Vaccines Whole Organism of Pathogen (MTb, 4000 proteins) Target proteins/antigens which can activate immune system Subunit Vaccine, Epitope Based Vaccines ( T B cell epitopes) Limitations of present methods of subunit vaccine design Developed for one or two MHC alleles (not suitable for large population) Do not consider pathways of antigen processing Difficult to detect experimentally known epitopes Initiatives taken by Bioinformatics Centre at IMT, Chandigarh India Understand complete mechanism of antigen processing Develop better and comprehensive methods;Epitopes (Subunit Vaccine);Multiple layers of the immune system;Immune Defense and Long Term Protection;Challenge in Vaccine Design;; Open source Web Services;Chemoinformatics and Pharmacoinformatics;Molecular Interactions;Biological Databases;Genome Annotations;Immunoinformatics or Vaccine Informatics;Functional Annotation of Proteins;Proteins Str