第4章以酶为靶点药物设计.pptVIP

; Section 1. Basic Knowledge of Enzyme;I. kinetics of enzyme-catalyzed reactions ;II. Interaction of E-I complex;Activation and Inhibition of Enzyme ;II. Inhibition of Enzyme;;Type of reversible inhibitors;I. Enzyme Inhibitor Drugs;II. Dsign Principles Enzyme Inhibitors;（一）基于非共价结合的酶抑制剂的合理设计：;;;II. Convalently Binding-Based Rational Design of Enzyme Inhibitors;;Section III. Design and Application Some Enzyme Inhibitor;I. ACEI ;II. 3D-Structure and Active Site of ACE;III. SAR of ACEI;II. PGs COX Inhibitors;Design of COX-2 Selective Inhibitors;2. Molecule Structure of COX-2 Inhibitors;III. HIV R