脂肪组织与胰岛素抵抗研究进展.pptVIP

内质网应激是IR发生的重要机制 Beck and Kaufman, 2012 未折叠反应： Unfolded protein response （UPR） 内质网跨膜信号蛋白：PERK，ATF6，IRE1 α 内质网应激与细胞凋亡 Carla J. H. van der Kallen，2009，Apoptosis Inflammation Proliferation, differentiation Adipocyte tissue dysfunction and insulin resistance Preadipocytes Small adipocytes S Sensitivity to insulin Obesity /T2DM /IR ↓proliferation,↑apoptosis ↓differentiation The percentage of small adipocytes↓, the size of adipocytes↑ Modified from Naoto Kubota, Molecular Cell 1999; Ishihara, Y，Atherosclerosis,2010; Lee MH, Kidney Int,2008; Okuno A J Clin Invest ,1998, Skurk T, J Clin E