11细胞衰老和死亡（cellaginganddeath）.pptxVIP

OB;?细胞衰老概念 Hayflick 界限 ?细胞衰老的体现 ?细胞衰老的机制;一、细胞衰老概念;、Hayflick界限（了解）;?支持的实验依据 /体外培养的胎儿肺二倍体 成纤维细胞； /不同物种的细胞在体外培 养条件下传代规律；;A支持的实验依据 / 早老症（Werner综合症）及Hayflick-Guilford症;2010-3-19;John Tacket, a child with progeria, at a press conference in 2003. Tacket, who at age 15 was the oldest person with the condition, died the following year. He often said he wanted people to know that progeria patients were like any other children.;HI;三、细胞衰老的体现（掌握）;细胞衰老的机制;?错误成灾学说 AOrgel在1963年提出：由于有机体内外环境损 伤因素的影响，造成遗传信息传递过程错误， 又由于衰老细胞修复功能降低，使得错误进一 步积累，并迅速扩大成灾，导致细胞衰老。;@自由基学说;?衰老是由于自由基对细胞的伤害所致;自由基的防护位点在细胞内的分布;2010-3-19;?端粒学说;