超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性英文.pptxVIP

超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性英文会计学Mechanisms of vessel wall neovascularization in atherosclerosisDoyle B et al. JACC 2007; 49:2073Possible roles for microvessels in disease progression include the supply of cellular and soluble lesion components, enhancement of intraplaque gas exchange, anddelivery of metabolic substrates to the plaque core.Doyle B et al. JACC 2007; 49:2073Neovascularization in Stable and Unstable Coronary PlaquesKolodgie FD et al. JACC 2007;49:2093Plaque neovascularization and clinical symptomsFleiner M et al. Circulation 2004;110:2843Number of microvessels identified from plaques of symptomatic and asymptomatic patients.McCarthy MJ et al. J Vasc Surg 1999;30:261Vessel Density at Histology According to Plaque Contrast-Agent EnhancementColi S et al. JACC 2008;52:223Vulnerable patients have vulnerable plaques Plaque neovascularization is the remarkably consistent feature of vulnerable plaque in cerebrovascular patients Contrast-enhanced carotid ultrasound imaging is promising and may serve to detect the neovascularization within the atherosclerotic plaque in vivo.Carotid plaque contrast-agent enhancement with sonographic agent correlates with histological density of neovessels within the carotid plaque The association between the carotid plaque enhancement with contrast agent microbubbles and clinical symptoms is not fully understood. Study Population研究方法GE Log9超声诊断仪9L探头：频率为6MHz机械指数：0.13104例患者快速静脉注射SonoVue 1.5 ml 实时观察颈动脉腔及斑块内造影剂显影情况Grading of Contrast-Agent Enhancement by Visual InterpretationGrade 1: no enhancement within the plaque or enhancement confined to plaque adventitial side and/or shoulderGrade 2: enhancement reaching plaque core/or extensive contrast agent enhancement throughout the plaque. Grading of Contrast-Agent Enhancement by Quantitative AnalysisEnhanced intensity in the plaqueRatio of the enhanced intensity in the plaque to that in the carotid artery lumen Receiver Operating Characteristic Curve AnalysisThe sensitivity and speci