北京大学《免疫学》移植免疫.pptVIP

* * * * * * * * * * * * Generation of cytotoxic T lymphocytes Another consequence of the MHC antigen and T cell interaction is the induction of cytotoxic T?lymphocytes. When T?lymphocytes are cultured in the presence of allogeneic lymphocytes, in addition to undergoing mitosis (MLR), they also become cytotoxic to cells of the type that stimulated MLR (Figure 3). Thus, T?lymphocytes of x haplotype cultured over 5?7 days with B lymphocytes of y haplotype will undergo mitosis and the surviving T?lymphocytes become cytotoxic to cells of the y haplotype. The induction of mitosis in MLR require