型糖尿病口服药物治疗.pptVIP

型糖尿病口服药物治疗;糖尿病诊断图解WHO Dept.of noncommunicable disease Surveillance. Geneva. 1999，;;; 正常人的胰岛素分泌特点;2021/1/12;2021/1/12;由胰岛素抵抗经IGT开展到糖尿病的过程;Insulin resistance with normal ?-cells:‘Climbing the curve’;Pathogenesis of type 2 diabetes:‘Falling off the curve’;Treatment of type 2 diabetes:‘Getting back on the curve’;Treatment of insulin resistance:‘Moving down the curve’; ;2021/1/12;N=254;2型糖尿病胰岛素1相分泌丧失;1相分泌的生理意义;Mitrakou A et al. Diabetes 1990;39:1381;血浆胰岛素;2型糖尿病B细胞缺陷;2型糖尿病脉冲幅度降低;糖尿病患者高频脉冲紊乱;对葡萄糖刺激敏感性的选择性丧失;胰岛素原增多;B细胞功能障碍的可能原因;2型糖尿病存在原发性B细胞缺陷;改善1相分泌可改善胰岛素敏感性;改善胰岛素抵抗也可恢复B细胞功能;早期2型糖尿病的治