阴茎癌指南讨论部分NCCN2021v2.pdfVIP

Overview Squamous cell carcinoma (SCC) of the penis is a rare disease, representing 0.4% to 0.6% of all malignant neoplasms among men in the United States and Europe.1 In 2020, the estimated number of new cases of penile and other male genital cancers inthe United States is 2200, with440 predicted cancer-specific deaths.2 Incidence is higher among men inthe developing countries of Asia, Africa, and SouthAmerica.3 The most common age of presentation is between 50 and 70 years.4 Early diagnosis is of utmost importance, as this is a disease that can result in devastating disfigurement and has a 5-year survival rate of approximately 50% (85% for patients with negative lymph nodes and 29%–40% for patients with positive nodes, with the lowest survival rates at 0% for patients with pelvic lymph node [PLN] involvement).5As the rarity of this disease makes it difficult to perform prospective, randomized trials, the NCCN Panel relied onthe experience of penile cancer experts and the best currently available evidence-based data to collectively lay down a foundation to help standardize the management of this malignancy. 概述 阴茎鳞状细胞癌 （SCC ）是一种罕见的疾病 ，在美国和欧洲男性中占所有恶性肿瘤的 0.4% 至 0.6%。1到 2020 年 ，估计美国阴茎癌和其他男性生殖器癌的新发病例为 2200 例 ，其 中440 例预测为癌症特异性死亡。2 在欧洲男性中发病率较高亚洲、非洲和南美洲的发展 中国家。3最常见的发病年龄在 50至 70 岁之间。4 早期诊断至关重要 ，因为这是一种可导 致毁灭性毁容的疾病 ，5年生存率约为 50% （淋巴结阴性患者为 85% ，淋巴结阴性患者 为 29%–40% ）淋巴结阳性的患者 ，盆腔淋巴结[PLN]受累患者的最低生存率为 0%。5 由 于这种疾病的罕见性 ，很难进行前瞻性随机试验 ，NCNN小组依赖于阴茎癌专家的经验和 目前最好的基于证据的数据来共同奠定一个基础 ，以帮助规范这种恶性肿瘤的管理。 Literature Search Criteria and Guidelines Update Methodology Prior to the update of this version of the NCCN Guidelines for Penile Cancer, an electronic search of the PubMed database was performed to obtain key literature using the following search term penile cancer. The PubMed database was chosen as it remains the most widely used resource for medical literature and indexes peer-reviewed biomedical literature.6 The search results were narrowed by selecting studies in